Background Obstructive sleep apnea-hypopnea syndrome (OSAHS) is an important public health problem. Plasma levels of vascular endothelial growth factor (pVEGF), which is believed to play an active role in the pathogenesis of cardiac pathologies developing in OSAHS. In this study, the correlation between pVEGF levels in OSAHS patients and polysomnographic values was examined. Materials and Methods Patients who applied to our center for the first time and consecutively who were “informed or referred from another unit” were admitted to this study. First, a standard questionnaire for the diagnosis of OSAHS and the Epworth Sleep Test were administered to the selected cases. Polysomnography (PSG) was performed in the Sleep Disorders Laboratory of our hospital. On the morning of the PSG test, blood was drawn to measure pVEGF levels. RESULTS The study was evaluated on 34 cases and 20 healthy individuals who were accepted as OSAHS with apnea-hypopnea index (AHI) value greater than 5. OSAHS patients who were admitted to the study, 5 were female and 29 were male. The pVEGF levels of the patients included in the study were higher than those of the control group. The AHI value and pVEGF levels were correlated. pVEGF levels were higher in patients with severe OSAHS were higher than mild OSAHS. There was a moderate correlation between desaturation and pVEGF levels. There was a moderate correlation between pVEGF levels and mean duration of apnea, number of total hypopneas, mean duration of hypopnea, apnea index, total apnea, and obstructive apnea. CONCLUSION We found that pVEGF levels were elevated in patients with OSAHS, which is considered to account for 1-5% of the population. pVEGF levels were directly correlated with the AHI value, which is linked to disease severity. In severe OSAHS cases, changes in pVEGF levels can be effective in the development of cardiovascular pathologies.