Background and Aims: Due to the high mortality and morbidity rates associated with cancer, it is crucial to advance research in this area to develop new and effective agents. Natural product chemistry plays a crucial role in identifying potential lead molecules for the treatment of various cancers. Recently, several studies have demonstrated the selective and potent cytotoxic activity of sesquiterpene coumarins isolated from Ferula species against various cancer cell lines. In this study, we aimed to utilize in silico molecular docking studies to demonstrate the potential of sesquiterpene coumarins as inhibitors of BclxL. For this purpose, 35 sesquiterpene coumarins were collected based on previous studies.