INTRODUCTION: This study aimed to determine the relationship between the tendency among women to undergo breast reconstruction after mastectomy and the quality of sexual life and social appearance anxiety. METHODS: This descriptive and cross-sectional study was conducted in 138 patients who underwent mastectomy at the general surgery and oncology department at ………………………………………. between May 2019 and July 2020. Data were collected using the “personal information form,” the “tendency to breast reconstruction after mastectomy scale (TBRAMS),” the “sexual quality of life-female (SQOL-F) scale,” and the “social appearance anxiety scale (SAAS).” Results: The mean scores on the TBRAMS, SQOL-F scale, and SAAS were 27.19 ± 2.68, 64.48 ± 9.26, and 46.10 ± 12.22, respectively. DISCUSSION AND CONCLUSION: The results showed that the mean TBRAMS, SQOL-F, and SAAS scores of the patients were at a moderate level, and a negative relationship was observed between the mean TBRAMS score and the SQOL-F scale and SAAS scores.