Objective: This study aimed to determine the quality of life, prevalence of depression, and level of independence in activities of daily living among individuals aged 65 and over and to examine related factors. Material and methods: This was a cross-sectional study. Three hundred and fifty-four individuals aged 65 and over were included in the study. In the study, socio-demographic questions, “World Health Organization Quality of Life-Old Module (WHOQOL-OLD)”, “Katz Index of Independence in Activities of Daily Living”, and “Yesavage Geriatric Depression Scale” were used. Results: The rate of dependence on activities of daily living among the elderly who participated in the study was 27.7%. The level of definitive depression in the elderly was 55.1%. Considering the WHOQOL-OLD total scores, educational level, nutrition, health assessment, pain, physical activity, leisure time, and use of mobile phones significantly affected the quality of life (p<0.05). The difference between age groups, marital status, people with whom they share the same house, pain status, and dependence on daily living activities was significant (p<0.05). The difference between age groups, gender, chronic disease status, health assessment, pain, sleeping pattern, physical activity, leisure time, and depression was significant (p<0.05). Conclusion: Quality of life, dependency status, and depression in the elderly are affected by many variables, and comprehensive and cross-sectoral studies are required.