Neuroleptic malignant syndrome is a rare but potentially fatal condition associated with the use of medications that affect the central dopaminergic system. It is characterized by symptoms such as hyperthermia, muscular rigidity, confusion, and autonomic instability. This case report presents a female patient diagnosed with schizophrenia who was initially treated with zuclopenthixol depot but could not tolerate its side effects. Therefore, her treatment was switched to long-acting injectable aripiprazole. Fifteen days after the administration of long-acting injectable aripiprazole, she presented to the emergency department with classic symptoms of neuroleptic malignant syndrome including fever, muscular rigidity, altered consciousness, hypertension, and hypersalivation. The clinical course of the case is described, and the findings are discussed in light of the existing literature.