Sheehan syndrome is caused by ischemic necrosis of the anterior pituitary gland following delivery hemorrhage. It represents a rare cause of hypopituitarism. The interval between the hemorrhagic event and the diagnosis of Sheehan syndrome can vary from a few months to many years.[1,2] The non-specific clinical presentations contribute to the underdiagnosis and underestimation of the true prevalence of this condition. Typically, women with Sheehan syndrome present with hypopituitarism affecting the lactotropin, corticotropin, thyrotropin, somatotropin, and gonadotropin axes Objectives: The aims of this study were to assess the 24-hour ambulatory BP levels and to determine the prevalence of abnormal circadian BP dipping patterns in women with hypopituitarism secondary to Sheehan syndrome. Methods: This was a cross-sectional study including 35 women with complete anterior hypopituitarism secondary to Sheehan syndrome and 47 age- and body-mass index-matched control women. Subjects receiving treatment for hypertension were not included. All participants underwent clinical examination, laboratory tests, and BP measurement using ambulatory 24-hour monitoring. Results: The mean age was 61.3+/-10.6 years in patients vs 60.5+/-8.5 years in controls (p=0.720). Compared to controls, women with Sheehan syndrome had a higher prevalence of dyslipidemia (p=0.032) and metabolic syndrome (p=0.028). The prevalence of hypertension was 68% in patients and 62% in controls (p=0.520). Altered day-night BP variation was more frequent in patients (85%) than in controls (54%) (p=0.004). Additionally, patients had a significantly higher prevalence of nocturnal hypertension (38% versus 3%; p=0.002). Sheehan syndrome was positively associated with a non-dipper and riser BP profile (Odds Ratio=4.7, 95% confidence interval: 1.54-14.33, p=0.004). Conclusion: Women with hypopituitarism secondary to Sheehan syndrome had a higher disruption of the circadian BP rhythm than controls. Although the prevalence of newly diagnosed hypertension was comparable between patients and controls, women with Sheehan syndrome had a higher prevalence of nocturnal hypertension.