Objective: This study aimed to analyse the quality of life, level of hopelessness and factors affecting patients receiving intravitreal injections. Method: This descriptive and cross-sectional study was conducted between 18.08.2022 and 10.10.2022 with 268 patients in Turkiye. Data were collected with the Personal Information Form, Beck Hopelessness Scale (BHS) and SF-36 Quality of Life Scale. T-test, one-way analysis of variance (ANOVA) and post hoc (Tukey, LSD) analyses were used to analyse the differences in scale levels according to the descriptive characteristics of the patients. Results: 54.1% of the patients were receiving intravitreal injection treatment for diabetic retinopathy, 28.4% for agerelated macular degeneration and 17.5% for branch retinal vein occlusion. The total mean BHS score was 11.452.71. Physical pain seems to affect the quality of life the most. Discussion: This is the first study investigating hopelessness and quality of life in intravitreal injection patients. Hopelessness level of the patients was moderate. The lowest quality of life was found in the emotional role subscale. Age, gender, occupation, educational status and reason for intraocular injections affect the quality of life.