Listeria monocytogenes is a Gram-positive, rod-shaped bacterium that can cause outbreaks through contaminated food. This report describes two cases of L. monocytogenes bacteremia successfully treated with a combination of meropenem and gentamicin. Both patients had underlying malignancies-multiple myeloma and breast cancer. Neither reported consuming unpasteurized milk or food from external sources. No relapse occurred in either case during a 6-month follow-up period. In conclusion, while L. monocytogenes bacteremia without associated meningitis or gastroenteritis is uncommon, it can occur in immunocompromised individuals. To our knowledge, these are the first reported cases of L. monocytogenes bacteremia in our country.