Meniscal pathologies are common and are associated with an increased risk of osteoarthritis with age.[1] Meniscal degeneration plays a significant role in knee pain. Meniscus tissue undergoes micro- and macro-scale degeneration with age, resulting in knee pain and dysfunction. [2] Non-surface, intrasubstance signal increases detected on Magnetic Resonance Imaging (MRI) are defined as grade 2 meniscus degeneration. [3] These lesions are considered a preliminary stage of meniscus tears, and no consensus has been reached regarding their treatment.[4,5] Non-operative therapy, focused on pharmacologic treatment (analgesics and/or non-steroidal anti-inflammatory drugs) and physical therapy, may provide pain relief as well as improve the mechanical function of the knee joint; however, it does not allow the degenerative process to regress. In addition, relatively weak intrinsic vascularity, hypocellularity, inflammatory mediators, and the combination of various proteases in the synovial fluid environment, along with complex mechanical loads, are factors that limit the spontaneous healing of the meniscus. Objectives: This study was conducted to evaluate the radiological and clinical results of platelet-rich plasma (PRP) therapy in degenerative meniscal lesions. Methods: Seventy patients with pain and grade 2 degenerative meniscal lesions on MRI (Magnetic Resonance Imaging) were included in the study. All patients underwent Knee Injury and Osteoarthritis Score (KOOS), Tegner-Lysholm, International Knee Documentation Committee Score (IKDC), Visual Analog Scale (VAS) clinical scores, and MRI scans before and 6 months after the injection. Results: There was a statistically significant increase in Tegner-Lysholm, KOOS, and IKDC scores after the procedure (p=0.001; p<0.01), and a statistically significant decrease in VAS score after the procedure (p=0.001; p<0.01). However, no statistically significant difference was observed in MRI parameters (p>0.05). Conclusion: It has been shown that the use of intra-articular PRP in painful degenerative meniscal lesions improves knee functions and helps reduce pain. However, no significant difference was observed in MRI controls. The results of our study indicate that the use of intra-articular PRP injection in patients with grade 2 meniscus degeneration improves clinical scores but does not result in significant improvement in degeneration as measured by MRI.