Objectives: This study aims to evaluate hand grip strength following transradial coronary procedures and to identify main factors influencing these changes. Patients and methods: Between December 2023 and March 2024, a total of 123 patients (92 males, 31 females; mean age: 63.0±9.2 years; range, 39 to 84 years) with stable angina pectoris who were scheduled for elective percutaneous transradial coronary intervention were included. Hand grip measurements were repeated one day after the transradial procedure and six months later. At six months of follow-up, the patients were divided into two groups based on the change in hand grip strength: those whose hand grip strength remained unchanged (n=84, Group 1) and those whose hand grip strength decreased (n=39, Group 2). The results were compared between the groups. Results: At the end of the follow-up, 31.7% of the 123 patients had reduced hand grip strength. Radial artery occlusion (RAO) occurred in 8.9% of patients and was significantly associated with reduced grip strength at six months (p=0.013). Active smokers also showed a persistent reduction in hand grip strength at six months (p=0.003). Independent predictors of reduced grip strength included RAO (p=0.038), current smoking (p<0.001), and prolonged hemostasis band removal time (p=0.008). Conclusion: Radial artery occlusion, current smoking, and prolonged hemostasis band removal time were identified as significant factors associated with the reduction in hand grip strength following the transradial approach. Recognizing these risk factors may help clinicians develop strategies to prevent hand function loss and support recovery more effectively.