Individuals with mental disorders often face greater stigma and discrimination from surrounding society compared with those experiencing medical illnesses. The prevalence of mental disorders is higher among young people. In OECD countries, approximately one in four individuals aged 15-24 years experiences a mental disorder, placing them at greater risk of dropping out of school and reducing their opportunities to secure stable employment. According to data from the World Health Organization (WHO), in 2019 there were 264 million people experiencing depression, 45 million people with bipolar disorder, 50 million people affected by dementia, and 20 million individuals with schizophrenia. Stigma and discrimination against individuals with mental disorders can create significant problems for those diagnosed with mental illness. These issues may lead to real-life disadvantages, including poor access to mental and physical healthcare, difficulties in obtaining or maintaining employment, challenges in securing accommodation, and reduced life expectancy. Additionally, stigma and negative treatment may cause individuals with mental disorders to experience relapse upon reintegration into society, as they may not receive adequate roles and social support from the community. Objectives: The issue of stigma related to mental disorders has increasingly become a global concern, despite significant improvements in mental health treatment and services. However, reductions in stigma associated with mental disorders have not kept pace with these advancements. Stigma refers to a negative label assigned to individuals, which may lead to their isolation from other social groups. This study aims to identify the predisposing factors that influence stigma toward individuals with mental disorders. Methods: A scoping review approach was used to identify various factors influencing the emergence of stigma, from both the perspective of individuals experiencing stigma and their social environments. Results: Based on the analysis of published studies, several key factors were identified, including demographic characteristics, disease-related factors, culture, education level, and family support, all of which play significant roles in either exacerbating or reducing stigma. Conclusion: The findings of this study provide deeper insight into the factors that should be addressed to reduce stigma related to mental disorders.