PURPOSE WHEN PERFORMNG THORACC AORTC ENDOVASCULAR REPAR (TEVAR) ON LESONS OF THE AORTC ARCH, PHYSCAN- MODFED FENESTRATON OR N STU FENESTRATON S OFTEN USED TO MANTAN PATENT BRANCHES. WE DESGNED A NEW ADJUSTABLE PREFENESTRATON AORTC STENT GRAFT THAT CAN BOTH SOLATE PATHOLOGES N THE AORTC ARCH AND OBTAN PATENT BRANCHES SMULTANEOUSLY. IN THS STUDY, WE USE THS NEW TYPE OF STENT TO PERFORM FENESTRATED TEVAR N A CANNE’S AORTA. THS STUDY AMS TO EVALUATE THE SAFETY AND FEASBLTY OF THE NEW DEVCE, WHCH MAY PROVDE PRELMNARY DATA FOR POTENTAL HUMAN APPLCATON. METHODS EGHT LABRADOR RETREVER CANNES UNDERWENT FENESTRATED TEVAR USNG THE NEW STENT DEVCE. DGTAL SUBTRACT ANGOGRAPHY (DSA) WAS PERFORMED BEFORE AND AFTER FENESTRATED TEVAR TO EVALUATE THE SAFETY AND FEASBLTY OF THE PROCEDURE. FOR THE DEVCE DEPLOYMENT, AT THE “LARGE CURVATURE” SDE N THE ENDOGRAFT, THERE S A RECTANGULAR PREFENESTRATON AREA (2 5 CM) WTHOUT THE POLYTETRAFLUOROETHYLENE MEMBRANE, AND AT BOTH LONGER SDE EDGES OF THE FENESTRATON, THERE ARE TWO SLDE RALS. A MOVEABLE MEMBRANE THAT COVERS THE SAME AREA AS THE PREFENESTRATON AREA S NTALLY SET AT THE PREFENESTRATON POSTON. A STAY LNE S CONNECTED FROM THE DSTAL STE OF THE MOVEABLE MEMBRANE THAT CONTROLS T TO THE DSTAL POSTON ALONG THE SLDE RAL, WHCH RELEASES THE FENESTRATON. AFTER THE POSTONNG OF THE PREFENESTRATON S DETERMNED, THE OUTER SHEATH OF THE DELVERY SYSTEM S RELEASED, AND THE STAY LNE AT THE END OF THE DELVERY SYSTEM S PULLED OUTSDE THE BODY. THE ANMALS WERE DVDED NTO A 1-MONTH GROUP (N = 4) AND A 3-MONTH GROUP (N = 4) AFTER THE FENESTRATED TEVAR. COMPUTED TOMOGRAPHY (CT) WAS PERFORMED BEFORE EUTHANASA, AND VDEO OF THE DSA DURNG THE PROCEDURES AND CT ANGOGRAPHY (CTA) MAGES WERE THEN STUDED. RESULTS THE PROCEDURE SUCCESS RATE WAS 100%, BUT THE TOTAL SURVVAL RATE WAS ONLY 87.5%. THERE WERE NO AORTC-RELATED DEATHS DURNG FOLLOW-UP, AND DURNG THE OPERATON, THERE WERE NO STENT-GRAFT-RELATED ACCDENTS. IN ADDTON, NO STENT-GRAFT MGRATONS WERE OBSERVED N THE CTA, AND ALL BRANCH ARTERES WERE KEPT PATENT BY THE ADJUSTABLE FENESTRATON. FNALLY, HSTOLOGCAL EXAMNATON AND ELECTRON MCROSCOPE RESULTS SHOWED NO OBVOUS VASCULAR NJURY OR NFLAMMATON. CONCLUSION BASED ON THE RESULTS OF THS STUDY, WE JUDGE THE SAFETY AND FEASBLTY OF THE USE OF THE NEWLY DESGNED ADJUSTABLE PREFENESTRATON AORTC STENT GRAFT N A FENESTRATED-TEVAR CANNE MODEL TO BE ACCEPTABLE. OUR PRELMNARY DATA MAY SERVE AS AN NTAL REFERENCE FOR EVALUATNG THE POTENTAL APPLCATON OF THE NEW STENT N HUMANS.
