Background Today, debate continues regarding the effective management of neovascular glaucoma (NVG) associated with proliferative diabetic retinopathy (PDR) and the success of the combination approach of pars plana (PP) Ahmed glaucoma valve (AGV) implantation and PP vitrectomy (PPV) in this patient. To evaluate the effect and tolerability of PP AGV implantation and PPV combined approach on intraocular pressure (IOP), visual acuity, and tolerability in patients with PDR and secondary uncontrolled NVG. Materials and Methods Thirty-seven patients with severe NVG secondary to PDR who were resistant to conventional medical therapies underwent surgery between May 2020 and January 2023. The surgical procedure involved 23-gauge PPV along with PP AGV implantation. Demographic information, surgical details, and complications were recorded. Statistical analyses were performed using the IBM SPSS statistics software. RESULTS The mean age of the patients was 52.8 years. Preoperatively, the mean IOP was 36.9±12.3 mmHg, decreasing significantly to 19.1±4.0 mmHg at the 12 month follow-up. The mean number of glaucoma medications reduced from 3.9±0.2 to 1.9±1.5 postoperatively. Best-corrected visual acuity improved in 17 patients, remained unchanged in 11, and deteriorated in 9. The complications included fibrinoid reaction, hyphema, transient hypotony, choroidal effusion, and one case requiring fibrotic band excision. No retinal complications or corneal insufficiency were reported. CONCLUSION The study concludes that the combined surgical approach of PP AGV implantation and 23-gauge PPV is a promising and effective strategy for managing uncontrolled NVG secondary to PDR. The method demonstrated positive outcomes in terms of IOP control, medication reduction, and visual improvement, with manageable complication rates.